Perspective on CFD studies of coronary artery disease lesions and hemodynamics: A review

Coronary artery disease (CAD) is the most common cardiovascular disease. Early diagnosis of CAD's physiological significance is of utmost importance for guiding individualized risk-tailored treatment strategies. In this paper, we first review the state-of-the-art clinical diagnostic indices to...

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Main Authors: Zhang, Jun-Mei, Zhong, Liang, Su, Boyang, Wan, Min, Yap, Jinq Shya, Tham, Jasmine P. L., Chua, Leok Poh, Ghista, Dhanjoo N., Tan, Ru San
Other Authors: School of Mechanical and Aerospace Engineering
Format: Article
Language:English
Published: 2016
Subjects:
CFD
Online Access:https://hdl.handle.net/10356/81644
http://hdl.handle.net/10220/40931
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-816442020-03-07T13:19:23Z Perspective on CFD studies of coronary artery disease lesions and hemodynamics: A review Zhang, Jun-Mei Zhong, Liang Su, Boyang Wan, Min Yap, Jinq Shya Tham, Jasmine P. L. Chua, Leok Poh Ghista, Dhanjoo N. Tan, Ru San School of Mechanical and Aerospace Engineering CFD coronary artery disease (CAD) Coronary artery disease (CAD) is the most common cardiovascular disease. Early diagnosis of CAD's physiological significance is of utmost importance for guiding individualized risk-tailored treatment strategies. In this paper, we first review the state-of-the-art clinical diagnostic indices to quantify the severity of CAD and the associated invasive and noninvasive imaging technologies in order to quantify the anatomical parameters of diameter stenosis, area stenosis, and hemodynamic indices of coronary flow reserve and fractional flow reserve. With the development of computational technologies and CFD methods, tremendous progress has been made in applying image-based CFD simulation techniques to elucidate the effects of hemodynamics in vascular pathophysiology toward the initialization and progression of CAD. So then, we review the advancements of CFD technologies in patient-specific modeling, involving the development of geometry reconstruction, boundary conditions, and fluid–structure interaction. Next, we review the applications of CFD to stenotic sites, in order to compute their hemodynamic parameters and study the relationship between the hemodynamic conditions and the clinical indices, to thereby assess the amount of viable myocardium and candidacy for percutaneous coronary intervention. Finally, we review the strengths and limitations of current researches of applying CFD to CAD studies. NRF (Natl Research Foundation, S’pore) ASTAR (Agency for Sci., Tech. and Research, S’pore) NMRC (Natl Medical Research Council, S’pore) 2016-07-13T09:00:41Z 2019-12-06T14:35:27Z 2016-07-13T09:00:41Z 2019-12-06T14:35:27Z 2014 Journal Article Zhang, J.-M., Zhong, L., Su, B., Wan, M., Yap, J. S., Tham, J. P. L., et al. (2014). Perspective on CFD studies of coronary artery disease lesions and hemodynamics: A review. International Journal for Numerical Methods in Biomedical Engineering, 30(6), 659-680. 2040-7939 https://hdl.handle.net/10356/81644 http://hdl.handle.net/10220/40931 10.1002/cnm.2625 en International Journal for Numerical Methods in Biomedical Engineering © 2014 John Wiley & Sons, Ltd.
institution Nanyang Technological University
building NTU Library
country Singapore
collection DR-NTU
language English
topic CFD
coronary artery disease (CAD)
spellingShingle CFD
coronary artery disease (CAD)
Zhang, Jun-Mei
Zhong, Liang
Su, Boyang
Wan, Min
Yap, Jinq Shya
Tham, Jasmine P. L.
Chua, Leok Poh
Ghista, Dhanjoo N.
Tan, Ru San
Perspective on CFD studies of coronary artery disease lesions and hemodynamics: A review
description Coronary artery disease (CAD) is the most common cardiovascular disease. Early diagnosis of CAD's physiological significance is of utmost importance for guiding individualized risk-tailored treatment strategies. In this paper, we first review the state-of-the-art clinical diagnostic indices to quantify the severity of CAD and the associated invasive and noninvasive imaging technologies in order to quantify the anatomical parameters of diameter stenosis, area stenosis, and hemodynamic indices of coronary flow reserve and fractional flow reserve. With the development of computational technologies and CFD methods, tremendous progress has been made in applying image-based CFD simulation techniques to elucidate the effects of hemodynamics in vascular pathophysiology toward the initialization and progression of CAD. So then, we review the advancements of CFD technologies in patient-specific modeling, involving the development of geometry reconstruction, boundary conditions, and fluid–structure interaction. Next, we review the applications of CFD to stenotic sites, in order to compute their hemodynamic parameters and study the relationship between the hemodynamic conditions and the clinical indices, to thereby assess the amount of viable myocardium and candidacy for percutaneous coronary intervention. Finally, we review the strengths and limitations of current researches of applying CFD to CAD studies.
author2 School of Mechanical and Aerospace Engineering
author_facet School of Mechanical and Aerospace Engineering
Zhang, Jun-Mei
Zhong, Liang
Su, Boyang
Wan, Min
Yap, Jinq Shya
Tham, Jasmine P. L.
Chua, Leok Poh
Ghista, Dhanjoo N.
Tan, Ru San
format Article
author Zhang, Jun-Mei
Zhong, Liang
Su, Boyang
Wan, Min
Yap, Jinq Shya
Tham, Jasmine P. L.
Chua, Leok Poh
Ghista, Dhanjoo N.
Tan, Ru San
author_sort Zhang, Jun-Mei
title Perspective on CFD studies of coronary artery disease lesions and hemodynamics: A review
title_short Perspective on CFD studies of coronary artery disease lesions and hemodynamics: A review
title_full Perspective on CFD studies of coronary artery disease lesions and hemodynamics: A review
title_fullStr Perspective on CFD studies of coronary artery disease lesions and hemodynamics: A review
title_full_unstemmed Perspective on CFD studies of coronary artery disease lesions and hemodynamics: A review
title_sort perspective on cfd studies of coronary artery disease lesions and hemodynamics: a review
publishDate 2016
url https://hdl.handle.net/10356/81644
http://hdl.handle.net/10220/40931
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