Engineering a vascular endothelial growth factor 165-binding heparan sulfate for vascular therapy

• Main Authors: Wang, Chunming, Poon, Selina, Murali, Sadasivam, Koo, Chuay-Yeng, Bell, Tracey J., Hinkley, Simon F., Yeong, Huiqing, Bhakoo, Kishore, Nurcombe, Victor, Cool, Simon M.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2016
• Subjects: Angiogenesis; Vasculogenesis
• Online Access: https://hdl.handle.net/10356/81666; http://hdl.handle.net/10220/40874
• Institution: Nanyang Technological University

The therapeutic use of VEGF165 to stimulate blood vessel formation for the treatment of peripheral arterial disease or cardiovascular-related disease has met with limited success. Here we describe an affinity-isolated heparan sulfate glycotherapeutic (HS7+ve) that binds to, and enhances the bioactiv...