Insight into the molecular interaction between the cyclic nucleotide-binding homology domain and the eag domain of the hERG channel

• Main Authors: Li, Qingxin, Ng, Hui Qi, Yoon, Ho Sup, Kang, CongBao
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2016
• Subjects: hERG; Cyclic nucleotide-binding homology domain
• Online Access: https://hdl.handle.net/10356/81668; http://hdl.handle.net/10220/40916
• Institution: Nanyang Technological University

The gating of the hERG channel is regulated by its eag domain through molecular interaction with either the cyclic nucleotide-binding homology domain (CNBHD) or the linker between transmembrane segments 4 and 5. Our NMR study on the purified CNBHD demonstrated that it contains nine β-strands and doe...