Spectral-domain optical coherence tomography with dual-balanced detection for auto-correlation artifacts reduction
We developed a spectral domain optical coherence tomography (SD-OCT) to reduce auto-correlation artifacts (AC) using dual-balanced detection (DBD). AC were composed of the interference signals between different sample tissue depths, and shown up as artifacts in OCT images. This system employed a fre...
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sg-ntu-dr.10356-816812020-03-07T11:35:20Z Spectral-domain optical coherence tomography with dual-balanced detection for auto-correlation artifacts reduction Bo, En Liu, Xinyu Chen, Si Yu, Xiaojun Wang, Xianghong Liu, Linbo School of Chemical and Biomedical Engineering School of Electrical and Electronic Engineering Optical coherence tomography Optical instrument We developed a spectral domain optical coherence tomography (SD-OCT) to reduce auto-correlation artifacts (AC) using dual-balanced detection (DBD). AC were composed of the interference signals between different sample tissue depths, and shown up as artifacts in OCT images. This system employed a free-space Michelson interferometer, at the refraction plane of whose beam splitter, the light reflected experienced a π/2 phase shift with respect to the light transmitted. Then two phase-opposed interferometric spectra sharing the same spectrometer optics were obtained simultaneously using two lines of a three-line CCD. This new design was of lower cost compared to the dual spectrometer design reported previously. DBD enabled this SD-OCT to achieve two-fold increase in the interested signal amplitude inherently, and obtain a SNR increase of ~2.9 dB experimentally. To demonstrate the feasibility and performance of this SD-OCT system with DBD, we conducted an imaging experiment using a glass plate to obtain the optimal spectral matching between dual-balanced spectrometer channels. As a result, this SD-OCT achieved AC reduction up to about 9 dB and direct current (DC) term suppression up to about 30 dB by cancelling the identical components between dual-balanced spectrometer channels. The efficacy of AC reduction and DC suppression was validated by imaging the polymer coating of a drug-eluting stent and fresh swine corneal tissue ex vivo. The quality of DBD optimized images was significantly improved with regard to the single-channel images. NRF (Natl Research Foundation, S’pore) MOE (Min. of Education, S’pore) NMRC (Natl Medical Research Council, S’pore) Accepted version 2016-07-20T04:04:00Z 2019-12-06T14:36:00Z 2016-07-20T04:04:00Z 2019-12-06T14:36:00Z 2015 Journal Article Bo, E., Liu, X., Chen, S., Yu, X., Wang, X., & Liu, L. (2015). Spectral-domain optical coherence tomography with dual-balanced detection for auto-correlation artifacts reduction. Optics Express, 23(21), 28050-28058. 1094-4087 https://hdl.handle.net/10356/81681 http://hdl.handle.net/10220/40975 10.1364/OE.23.028050 en Optics Express © 2015 Optical Society of America. This is the author created version of a work that has been peer reviewed and accepted for publication by Optics Express, Optical Society of America. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1364/OE.23.028050]. 9 p. application/pdf |
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Optical coherence tomography Optical instrument Bo, En Liu, Xinyu Chen, Si Yu, Xiaojun Wang, Xianghong Liu, Linbo Spectral-domain optical coherence tomography with dual-balanced detection for auto-correlation artifacts reduction |
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We developed a spectral domain optical coherence tomography (SD-OCT) to reduce auto-correlation artifacts (AC) using dual-balanced detection (DBD). AC were composed of the interference signals between different sample tissue depths, and shown up as artifacts in OCT images. This system employed a free-space Michelson interferometer, at the refraction plane of whose beam splitter, the light reflected experienced a π/2 phase shift with respect to the light transmitted. Then two phase-opposed interferometric spectra sharing the same spectrometer optics were obtained simultaneously using two lines of a three-line CCD. This new design was of lower cost compared to the dual spectrometer design reported previously. DBD enabled this SD-OCT to achieve two-fold increase in the interested signal amplitude inherently, and obtain a SNR increase of ~2.9 dB experimentally. To demonstrate the feasibility and performance of this SD-OCT system with DBD, we conducted an imaging experiment using a glass plate to obtain the optimal spectral matching between dual-balanced spectrometer channels. As a result, this SD-OCT achieved AC reduction up to about 9 dB and direct current (DC) term suppression up to about 30 dB by cancelling the identical components between dual-balanced spectrometer channels. The efficacy of AC reduction and DC suppression was validated by imaging the polymer coating of a drug-eluting stent and fresh swine corneal tissue ex vivo. The quality of DBD optimized images was significantly improved with regard to the single-channel images. |
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School of Chemical and Biomedical Engineering |
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School of Chemical and Biomedical Engineering Bo, En Liu, Xinyu Chen, Si Yu, Xiaojun Wang, Xianghong Liu, Linbo |
format |
Article |
author |
Bo, En Liu, Xinyu Chen, Si Yu, Xiaojun Wang, Xianghong Liu, Linbo |
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Bo, En |
title |
Spectral-domain optical coherence tomography with dual-balanced detection for auto-correlation artifacts reduction |
title_short |
Spectral-domain optical coherence tomography with dual-balanced detection for auto-correlation artifacts reduction |
title_full |
Spectral-domain optical coherence tomography with dual-balanced detection for auto-correlation artifacts reduction |
title_fullStr |
Spectral-domain optical coherence tomography with dual-balanced detection for auto-correlation artifacts reduction |
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Spectral-domain optical coherence tomography with dual-balanced detection for auto-correlation artifacts reduction |
title_sort |
spectral-domain optical coherence tomography with dual-balanced detection for auto-correlation artifacts reduction |
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2016 |
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https://hdl.handle.net/10356/81681 http://hdl.handle.net/10220/40975 |
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1681047856824188928 |