Butelase 1: A Versatile Ligase for Peptide and Protein Macrocyclization

• المؤلفون الرئيسيون: Nguyen, Giang Kien Truc, Kam, Antony, Tam, James Pingkwan, Loo, Shining, Jansson, Anna Elisabet, Pan, Lucy Xin
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2016
• الموضوعات: Biological Sciences
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/81713; http://hdl.handle.net/10220/39652

Macrocyclization is a valuable tool for drug design and protein engineering. Although various methods have been developed to prepare macrocycles, a general and efficient strategy is needed. Here we report a highly efficient method using butelase 1 to macrocyclize peptides and proteins ranging in siz...