The nuage mediates retrotransposon silencing in mouse primordial ovarian follicles

• Main Authors: Lim, Ai Khim, Lorthongpanich, Chanchao, Chew, Ting Gang, Tan, Chin Wee Godwin, Shue, Yan Ting, Balu, Sathish, Gounko, Natalia, Kuramochi-Miyagawa, Satomi, Matzuk, Martin M., Chuma, Shinichiro, Messerschmidt, Daniel M., Solter, Davor, Knowles, Barbara B.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2016
• Subjects: Ovary; Nuage
• Online Access: https://hdl.handle.net/10356/81827; http://hdl.handle.net/10220/40996
• Institution: Nanyang Technological University

Mobilization of endogenous retrotransposons can destabilize the genome, an imminent danger during epigenetic reprogramming of cells in the germline. The P-element-induced wimpy testis (PIWI)-interacting RNA (piRNA) pathway is known to silence retrotransposons in the mouse testes. Several piRNA pathw...