Graphene quantum dots for ultrasensitive detection of acetylcholinesterase and its inhibitors

Graphene quantum dots for ultrasensitive detection of acetylcholinesterase and its inhibitors

Graphene quantum dots (GQDs) are emerging zero-dimensional materials promising a wide spectrum of novel applications including development of optical sensors. Herein, a GQD-based fluorometric sensor is devised to detect acetylcholinesterase (AChE, a critical enzyme in central nervous system and neur...

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Bibliographic Details
Main Authors: Li, Nan, Wang, Xuewan, Chen, Jie, Sun, Lei, Chen, Peng
Other Authors: School of Chemical and Biomedical Engineering
Format: Article
Language:English
Published: 2016
Subjects:
2D Materials
Acetylcholinesterase
Fluorometric sensor
Online Access:https://hdl.handle.net/10356/81884
http://hdl.handle.net/10220/39723
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Institution: Nanyang Technological University
Language: English
Description
Summary:Graphene quantum dots (GQDs) are emerging zero-dimensional materials promising a wide spectrum of novel applications including development of optical sensors. Herein, a GQD-based fluorometric sensor is devised to detect acetylcholinesterase (AChE, a critical enzyme in central nervous system and neuromuscular junctions) with an ultralow detection limit (0.58 pM with S/N of 5.0), using a photoluminescence 'turn-off' mechanism. This simple 'mix-and-detect' platform can also be employed to sense a variety of compounds that can directly or indirectly inhibit the enzymatic activities of AChE, such as nerve gases, pesticides, and therapeutic drugs. As the proof-of-concept demonstrations, we show the sensitive detection of paraoxon (a pesticide), tacrine (a drug to treat Alzheimer's disease), and dopamine (an important neurotransmitter).

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