Complexation of Polyelectrolytes with Hydrophobic Drug Molecules in Salt-Free Solution: Theory and Simulations

• Main Authors: Lei, Qun-li, Hadinoto, Kunn, Ni, Ran
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2017
• Subjects: Colloidal PE–drug complex; Polyelectrolyes (PE)
• Online Access: https://hdl.handle.net/10356/81902; http://hdl.handle.net/10220/42289
• Institution: Nanyang Technological University

The delivery and dissolution of poorly soluble drugs is challenging in the pharmaceutical industry. One way to significantly improve the delivery efficiency is to incorporate these hydrophobic small molecules into a colloidal polyelectrolyes(PE)–drug complex in their ionized states. Despite its huge...