Insight into membrane selectivity of linear and branched polyethylenimines and their potential as biocides for advanced wound dressings

• Main Authors: Fox, Stephen John, Fazil, Mobashar Hussain Urf Turabe, Dhand, Chetna, Venkatesh, Mayandi, Goh, Eunice Tze Leng, Harini, Sriram, Eugene, Christo, Lim, Rayne Rui, Ramakrishna, Seeram, Chaurasia, Shyam Sunder, Beuerman, Roger W., Verma, Chandra Shekhar, Verma, Navin Kumar, Loh, Xian Jun, Lakshminarayanan, Rajamani
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2016
• Subjects: Molecular dynamics; Membrane selectivity
• Online Access: https://hdl.handle.net/10356/81965; http://hdl.handle.net/10220/41038
• Institution: Nanyang Technological University

We report here structure-property relationship between linear and branched polyethylene imines by examining their antimicrobial activities against wide range of pathogens. Both the polymers target the cytoplasmic membrane of bacteria and yeasts, eliciting rapid microbicidal properties. Using multisc...