p27 is regulated independently of Skp2 in the absence of Cdk2

• Main Authors: Kaldis, Philipp, Kotoshiba, Shuhei, Gopinathan, Lakshmi, Pfeiffenberger, Elisabeth, Rahim, Anisa, Vardy, Leah Karen Anne, Nakayama, Keiko, Nakayama, Keiichi I.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2016
• Subjects: Cyclin-dependent kinase; Knockout mice
• Online Access: https://hdl.handle.net/10356/81991; http://hdl.handle.net/10220/41082
• Institution: Nanyang Technological University

Cyclin-dependent kinase 2 (Cdk2) is dispensable for mitotic cell cycle progression and Cdk2 knockout mice are viable due to the compensatory functions of other Cdks. In order to assess the role of Cdk2 under limiting conditions, we used Skp2 knockout mice that exhibit increased levels of Cdk inhibit...