Clec9A + dendritic cells are not essential for antitumor CD8 + T cell responses induced by poly I:C immunotherapy

• Main Authors: Gilfillan, Connie B., Kuhn, Sabine, Baey, Camille, Hyde, Evelyn J., Yang, Jianping, Ruedl, Christiane, Ronchese, Franca
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2019
• Subjects: Science::Biological sciences; Dendritic Cells; CD8+ T Cell
• Online Access: https://hdl.handle.net/10356/82502; http://hdl.handle.net/10220/49073
• Institution: Nanyang Technological University

In the steady state, tumors harbor several populations of dendritic cells (DCs) and myeloid cells that are key regulators of the intratumoral immune environment. Among these cells, migratory CD103+ cross-presenting DCs are thought to be critical for tumor-specific CTL responses and tumor resistance....