Inter-Dependent Mechanisms Behind Cognitive Dysfunction, Vascular Biology and Alzheimer's Dementia in Down Syndrome: Multi-Faceted Roles of APP

• Main Authors: Nizetic, Dean, Chen, Christopher L., Hong, Wanjin, Koo, Edward H.
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2016
• Subjects: Down syndrome; Vascular dementia; Neuron activity-dependent; Cognitive dysfunction; Amyloid beta-peptides; Amyloid beta-protein precursor
• Online Access: https://hdl.handle.net/10356/82597; http://hdl.handle.net/10220/40342
• Institution: Nanyang Technological University

People with Down syndrome (DS) virtually all develop intellectual disability (ID) of varying degree of severity, and also have a high risk of early Alzheimer's disease (AD). ID prior to the onset of dementia, and its relationship to the onset of dementia in DS is a complex phenomenon influenced...