A concise route to the highly-functionalized azetidine precursor: the enantioselective synthesis of penaresidin B

• Main Authors: Ding, Feiqing, William, Ronny, Kock, Si Min, Leow, Min Li, Liu, Xue-Wei
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2016
• Subjects: azetidine; glycosylation
• Online Access: https://hdl.handle.net/10356/82679; http://hdl.handle.net/10220/40279
• Institution: Nanyang Technological University

An efficient and high-yielding synthesis of penaresidin B is disclosed herein. The concise 8-step synthesis of azetidine aldehyde was devised by incorporating our novel strategy for ready access to 3-amino-2,3-dideoxysugars via regio- and stereoselective tandem hydroamination/glycosylation of glycal...