Cancer-targeted design of bioresponsive prodrug with enhanced cellular uptake to achieve precise cancer therapy

• Main Authors: Liang, Yuanwei, Huang, Wei, Zeng, Delong, Huang, Xiaoting, Chan, Leung, Mei, Chaoming, Feng, Pengju, Tan, Choon-Hong, Chen, Tianfeng
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2019
• Subjects: Science::Chemistry::Biochemistry; Adverse Effects; Cancer-targeted
• Online Access: https://hdl.handle.net/10356/82749; http://hdl.handle.net/10220/49088
• Institution: Nanyang Technological University

Chemical drug design based on the biochemical characteristics of cancer cells has become an important strategy for discovery of novel anticancer drugs to enhance the cancer targeting effects and biocompatibility, and decrease toxic side effects. Camptothecin (CPT) demonstrated strong anticancer acti...