The p53–Mdm2 interaction and the E3 ligase activity of Mdm2/Mdm4 are conserved from lampreys to humans

• Main Authors: Venkatesh, Byrappa, Lane, David P., Coffill, Cynthia R., Lee, Alison P., Siau, Jia Wei, Chee, Sharon M., Joseph, Thomas L., Tan, Yaw Sing, Madhumalar, Arumugam, Tay, Boon-Hui, Brenner, Sydney, Verma, Chandra Shekhar, Ghadessy, Farid J.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2016
• Subjects: P53; Mdm2; Mdm4; Evolution; Lamprey
• Online Access: https://hdl.handle.net/10356/82782; http://hdl.handle.net/10220/40297
• Institution: Nanyang Technological University

The extant jawless vertebrates, represented by lampreys and hagfish, are the oldest group of vertebrates and provide an interesting genomic evolutionary pivot point between invertebrates and jawed vertebrates. Through genome analysis of one of these jawless vertebrates, the Japanese lamprey (Lethent...