Modulating Drug Release from Gastric-Floating Microcapsules through Spray-Coating Layers

• Main Authors: Lee, Wei Li, Tan, Jun Wei Melvin, Tan, Chaoyang Nicholas, Loo, Say Chye Joachim
• Other Authors: Mohapatra, Subhra
• Format: Article
• Language: English
• Published: 2016
• Subjects: Coatings; Drug delivery; Polymers; Buoyancy; Drug-drug interaction; Vegetable oils; Drug absorption; Microencapsulation
• Online Access: https://hdl.handle.net/10356/82825; http://hdl.handle.net/10220/40329
• Institution: Nanyang Technological University

Floating dosage forms with prolonged gastric residence time have garnered much interest in the field of oral delivery. However, studies had shown that slow and incomplete release of hydrophobic drugs during gastric residence period would reduce drug absorption and cause drug wastage. Herein, a spray...