Synthesis of Gold Nanoparticle Integrated Photo-responsive Liposomes and Measurement of Their Microbubble Cavitation upon Pulse Laser Excitation

Photo-responsive nanoparticles (NPs) have received considerable attention because of their potential in providing spatial, temporal, and dosage control over the drug release. However, most of the relevant technologies are still in the development process and are unprocurable by clinics. Here, we des...

Full description

Saved in:
Bibliographic Details
Main Authors: Mathiyazhakan, Malathi, Chan, Weiwei, Ohl, Claus-Dieter, Xu, Chenjie
Other Authors: School of Chemical and Biomedical Engineering
Format: Article
Language:English
Published: 2016
Subjects:
Online Access:https://hdl.handle.net/10356/82827
http://hdl.handle.net/10220/40305
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Nanyang Technological University
Language: English
id sg-ntu-dr.10356-82827
record_format dspace
spelling sg-ntu-dr.10356-828272023-02-28T20:02:32Z Synthesis of Gold Nanoparticle Integrated Photo-responsive Liposomes and Measurement of Their Microbubble Cavitation upon Pulse Laser Excitation Mathiyazhakan, Malathi Chan, Weiwei Ohl, Claus-Dieter Xu, Chenjie School of Chemical and Biomedical Engineering School of Physical and Mathematical Sciences NTU-Northwestern Institute for Nanomedicine Issue 108 Exogenous stimuli-responsive nanoparticles controlled release Bioengineering microbubble cavitation light-responsive liposomes gold nanoparticles drug delivery Photo-responsive nanoparticles (NPs) have received considerable attention because of their potential in providing spatial, temporal, and dosage control over the drug release. However, most of the relevant technologies are still in the development process and are unprocurable by clinics. Here, we describe a facile fabrication of these photo-responsive NPs with commercially available gold NPs and thermo-responsive liposomes Calcein is used as a model drug to evaluate the encapsulation efficiency and the release kinetic profile upon heat/light stimulation. Finally, we show that this photo-triggered release is due to the membrane disruption caused by microbubble cavitation, which can be measured with hydrophone. MOE (Min. of Education, S’pore) Published version 2016-03-18T07:30:59Z 2019-12-06T15:06:24Z 2016-03-18T07:30:59Z 2019-12-06T15:06:24Z 2016 Journal Article Mathiyazhakan, M., Chan, W., Ohl, C.-D., & Xu, C. (2016). Synthesis of Gold Nanoparticle Integrated Photo-responsive Liposomes and Measurement of Their Microbubble Cavitation upon Pulse Laser Excitation. Journal of Visualized Experiments, (108), e53619-. 1940-087X https://hdl.handle.net/10356/82827 http://hdl.handle.net/10220/40305 10.3791/53619 26967978 en Journal of Visualized Experiments © 2016 Journal of Visualized Experiments. This paper was published in Journal of Visualized Experiments and is made available as an electronic reprint (preprint) with permission of Journal of Visualized Experiments. The published version is available at: [http://dx.doi.org/10.3791/53619]. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law. 5 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Issue 108
Exogenous stimuli-responsive nanoparticles
controlled release
Bioengineering
microbubble cavitation
light-responsive liposomes
gold nanoparticles
drug delivery
spellingShingle Issue 108
Exogenous stimuli-responsive nanoparticles
controlled release
Bioengineering
microbubble cavitation
light-responsive liposomes
gold nanoparticles
drug delivery
Mathiyazhakan, Malathi
Chan, Weiwei
Ohl, Claus-Dieter
Xu, Chenjie
Synthesis of Gold Nanoparticle Integrated Photo-responsive Liposomes and Measurement of Their Microbubble Cavitation upon Pulse Laser Excitation
description Photo-responsive nanoparticles (NPs) have received considerable attention because of their potential in providing spatial, temporal, and dosage control over the drug release. However, most of the relevant technologies are still in the development process and are unprocurable by clinics. Here, we describe a facile fabrication of these photo-responsive NPs with commercially available gold NPs and thermo-responsive liposomes Calcein is used as a model drug to evaluate the encapsulation efficiency and the release kinetic profile upon heat/light stimulation. Finally, we show that this photo-triggered release is due to the membrane disruption caused by microbubble cavitation, which can be measured with hydrophone.
author2 School of Chemical and Biomedical Engineering
author_facet School of Chemical and Biomedical Engineering
Mathiyazhakan, Malathi
Chan, Weiwei
Ohl, Claus-Dieter
Xu, Chenjie
format Article
author Mathiyazhakan, Malathi
Chan, Weiwei
Ohl, Claus-Dieter
Xu, Chenjie
author_sort Mathiyazhakan, Malathi
title Synthesis of Gold Nanoparticle Integrated Photo-responsive Liposomes and Measurement of Their Microbubble Cavitation upon Pulse Laser Excitation
title_short Synthesis of Gold Nanoparticle Integrated Photo-responsive Liposomes and Measurement of Their Microbubble Cavitation upon Pulse Laser Excitation
title_full Synthesis of Gold Nanoparticle Integrated Photo-responsive Liposomes and Measurement of Their Microbubble Cavitation upon Pulse Laser Excitation
title_fullStr Synthesis of Gold Nanoparticle Integrated Photo-responsive Liposomes and Measurement of Their Microbubble Cavitation upon Pulse Laser Excitation
title_full_unstemmed Synthesis of Gold Nanoparticle Integrated Photo-responsive Liposomes and Measurement of Their Microbubble Cavitation upon Pulse Laser Excitation
title_sort synthesis of gold nanoparticle integrated photo-responsive liposomes and measurement of their microbubble cavitation upon pulse laser excitation
publishDate 2016
url https://hdl.handle.net/10356/82827
http://hdl.handle.net/10220/40305
_version_ 1759853375210389504