Lipopolysaccharide-affinity copolymer senses the rapid motility of swarmer bacteria to trigger antimicrobial drug release

• Main Authors: Yeow, Edwin Kok Lee, Lu, Shengtao, Bi, Wuguo, Du, Quanchao, Sinha, Sheetal, Wu, Xiangyang, Subrata, Arnold, Bhattacharjya, Surajit, Xing, Bengang
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2019
• Subjects: DRNTU::Science::Chemistry::Biochemistry; Swarmer Bacteria; Drug Release
• Online Access: https://hdl.handle.net/10356/82960; http://hdl.handle.net/10220/47529
• Institution: Nanyang Technological University

An intelligent drug release system that is triggered into action upon sensing the motion of swarmer P. mirabilis is introduced. The rational design of the drug release system focuses on a pNIPAAm-co-pAEMA copolymer that prevents drug leakage in a tobramycin-loaded mesoporous silica particle by cover...