Expanding heme-protein folding space using designed multi-heme β-sheet mini-proteins

• المؤلفون الرئيسيون: D’Souza, Areetha, Torres, Jaume, Bhattacharjya, Surajit
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2019
• الموضوعات: Biophysical Chemistry; Solution-state NMR; Science::Biological sciences
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/82967; http://hdl.handle.net/10220/49100

Nature has primarily exploited helical proteins, over β-sheets, for heme/multi-heme coordination. Understating of heme–protein structures has motivated the design of heme proteins utilizing coiled-coil helical structure. By contrast, de novo designed β-sheet proteins are less successful. However, de...