Bedaquiline Targets the ε Subunit of Mycobacterial F-ATP Synthase

• Main Authors: Kundu, Subhashri, Biukovic, Goran, Grüber, Gerhard, Dick, Thomas
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2017
• Subjects: F-ATP synthase; ε subunit
• Online Access: https://hdl.handle.net/10356/83045; http://hdl.handle.net/10220/42376
• Institution: Nanyang Technological University

The tuberculosis drug bedaquiline inhibits mycobacterial F-ATP synthase by binding to its c subunit. Using the purified ε subunit of the synthase and spectroscopy, we previously demonstrated that the drug interacts with this protein near its unique tryptophan residue. Here, we show that replacement...