A zebrafish model for a human myopathy associated with mutation of the unconventional myosin MYO18B

• Main Authors: Gurung, Ritika, Ono, Yosuke, Baxendale, Sarah, Lee, Samantha Lin Chiou, Moore, Steven, Calvert, Meredith, Ingham, Philip William
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2019
• Subjects: Nemaline Myopathy; MYO18B; Science::Medicine
• Online Access: https://hdl.handle.net/10356/83141; http://hdl.handle.net/10220/49114
• Institution: Nanyang Technological University

Myosin 18B is an unconventional myosin that has been implicated in tumor progression in humans. In addition, loss-of-function mutations of the MYO18B gene have recently been identified in several patients exhibiting symptoms of nemaline myopathy. In mouse, mutation of Myo18B results in early develop...