Mesoscopic energy minimization drives pseudomonas aeruginosa biofilm morphologies and consequent stratification of antibiotic activity based on cell metabolism

• Main Authors: Sheraton, Muniraj Vivek, Yam, Joey Kuok Hoong, Tan, Chuan Hao, Oh, H. S., Mancini, E., Yang, Liang, Rice, Scott A., Sloot, Peter M. A.
• Other Authors: School of Materials Science & Engineering
• Format: Article
• Language: English
• Published: 2018
• Subjects: Cellular Potts Model; Mushroom-shaped Biofilm
• Online Access: https://hdl.handle.net/10356/83169; http://hdl.handle.net/10220/45074
• Institution: Nanyang Technological University

Segregation of bacteria based on their metabolic activities in biofilms plays an important role in the development of antibiotic resistance. Mushroom-shaped biofilm structures, which are reported for many bacteria, exhibit topographically varying levels of multiple drug resistance from the cap of th...