Role of lncRNAs in Cellular Aging

Aging is a universal, intrinsic, and time-dependent biological decay that is linked to intricate cellular processes including cellular senescence, telomere shortening, stem cell exhaustion, mitochondrial dysfunction, and deregulated metabolism. Cellular senescence is accepted as one of the core proc...

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Main Authors: Degirmenci, Ufuk, Lei, Sun
Other Authors: School of Chemical and Biomedical Engineering
Format: Article
Language:English
Published: 2017
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Online Access:https://hdl.handle.net/10356/83179
http://hdl.handle.net/10220/42475
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-831792023-12-29T06:45:50Z Role of lncRNAs in Cellular Aging Degirmenci, Ufuk Lei, Sun School of Chemical and Biomedical Engineering Senescence Aging lncRNA Aging is a universal, intrinsic, and time-dependent biological decay that is linked to intricate cellular processes including cellular senescence, telomere shortening, stem cell exhaustion, mitochondrial dysfunction, and deregulated metabolism. Cellular senescence is accepted as one of the core processes of aging at the organism level. Understanding the molecular mechanism underlying senescence could facilitate the development of potential therapeutics for aging and age-related diseases. Recently, the discovery of long non-coding RNAs (lncRNA) provided insights into a novel regulatory layer that can intervene with cellular senescence. Increasing evidence indicates that targeting lncRNAs may impact on senescence pathways. In this review, we will focus on lncRNAs involved in mechanistic pathways governing cellular senescence. NMRC (Natl Medical Research Council, S’pore) Published version 2017-05-24T02:02:49Z 2019-12-06T15:13:27Z 2017-05-24T02:02:49Z 2019-12-06T15:13:27Z 2016 Journal Article Degirmenci, U.,& Lei, S. (2016). Role of lncRNAs in Cellular Aging. Frontiers in Endocrinology, 7. 1664-2392 https://hdl.handle.net/10356/83179 http://hdl.handle.net/10220/42475 10.3389/fendo.2016.00151 en Frontiers in Endocrinology © 2016 Degirmenci and Lei. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. 10 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Senescence
Aging
lncRNA
spellingShingle Senescence
Aging
lncRNA
Degirmenci, Ufuk
Lei, Sun
Role of lncRNAs in Cellular Aging
description Aging is a universal, intrinsic, and time-dependent biological decay that is linked to intricate cellular processes including cellular senescence, telomere shortening, stem cell exhaustion, mitochondrial dysfunction, and deregulated metabolism. Cellular senescence is accepted as one of the core processes of aging at the organism level. Understanding the molecular mechanism underlying senescence could facilitate the development of potential therapeutics for aging and age-related diseases. Recently, the discovery of long non-coding RNAs (lncRNA) provided insights into a novel regulatory layer that can intervene with cellular senescence. Increasing evidence indicates that targeting lncRNAs may impact on senescence pathways. In this review, we will focus on lncRNAs involved in mechanistic pathways governing cellular senescence.
author2 School of Chemical and Biomedical Engineering
author_facet School of Chemical and Biomedical Engineering
Degirmenci, Ufuk
Lei, Sun
format Article
author Degirmenci, Ufuk
Lei, Sun
author_sort Degirmenci, Ufuk
title Role of lncRNAs in Cellular Aging
title_short Role of lncRNAs in Cellular Aging
title_full Role of lncRNAs in Cellular Aging
title_fullStr Role of lncRNAs in Cellular Aging
title_full_unstemmed Role of lncRNAs in Cellular Aging
title_sort role of lncrnas in cellular aging
publishDate 2017
url https://hdl.handle.net/10356/83179
http://hdl.handle.net/10220/42475
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