An RRM–ZnF RNA recognition module targets RBM10 to exonic sequences to promote exon exclusion

• Main Authors: Collins, Katherine M., Kainov, Yaroslav A., Christodolou, Evangelos, Ray, Debashish, Morris, Quaid, Hughes, Timothy, Taylor, Ian A., Makeyev, Eugene V., Ramos, Andres
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2017
• Subjects: Introns; RNA Splicing; Exons
• Online Access: https://hdl.handle.net/10356/83187; http://hdl.handle.net/10220/42476
• Institution: Nanyang Technological University

RBM10 is an RNA-binding protein that plays an essential role in development and is frequently mutated in the context of human disease. RBM10 recognizes a diverse set of RNA motifs in introns and exons and regulates alternative splicing. However, the molecular mechanisms underlying this seemingly rel...