Mechanics of diseased red blood cells in human spleen and consequences for hereditary blood disorders

• Main Authors: Li, He, Lu, Lu, Li, Xuejin, Buffet, Pierre A., Dao, Ming, Karniadakis, George E., Suresh, Subra
• Other Authors: School of Materials Science & Engineering
• Format: Article
• Language: English
• Published: 2019
• Subjects: Engineering::Materials; Spleen; Hereditary Spherocytosis
• Online Access: https://hdl.handle.net/10356/83299; http://hdl.handle.net/10220/50097
• Institution: Nanyang Technological University

In red blood cell (RBC) diseases, the spleen contributes to anemia by clearing the damaged RBCs, but its unique ability to mechanically challenge RBCs also poses the risk of inducing other pathogenic effects. We have analyzed RBCs in hereditary spherocytosis (HS) and hereditary elliptocytosis (HE),...