Simultaneous polymerization and adhesion under hypoxia in sickle cell disease

• Main Authors: Papageorgiou, Dimitrios P., Abidi, Sabia Z., Chang, Hung-Yu, Li, Xuejin, Kato, Gregory J., Karniadakis, George E., Suresh, Subra, Dao, Ming
• Other Authors: School of Materials Science & Engineering
• Format: Article
• Language: English
• Published: 2019
• Subjects: Dissipative Particle Dynamics; Sickle Cell Adhesion Dynamics; Engineering::Materials
• Online Access: https://hdl.handle.net/10356/83300; http://hdl.handle.net/10220/50096
• Institution: Nanyang Technological University

Polymerization and adhesion, dynamic processes that are hallmarks of sickle cell disease (SCD), have thus far been studied in vitro only separately. Here, we present quantitative results of the simultaneous and synergistic effects of adhesion and polymerization of deoxygenated sickle hemoglobin (HbS...