Hemodynamic shear stress stimulates migration and extravasation of tumor cells by elevating cellular oxidative level

• Main Authors: Ma, Shijun, Fu, Afu, Chiew, Geraldine Giap Ying, Luo, Kathy Qian
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2017
• Subjects: Circulating tumor cells; Shear stress
• Online Access: https://hdl.handle.net/10356/83325; http://hdl.handle.net/10220/42525
• Institution: Nanyang Technological University

Cancer cells are shed into the blood stream and are exposed to hemodynamic shear stress during metastasis. It has been shown that shear stress can destroy circulating tumor cells (CTCs) both in vitro and in vivo. However, it remains unclear whether shear stress can modulate the properties and functi...