Endosome-ER Contacts Control Actin Nucleation and Retromer Function through VAP-Dependent Regulation of PI4P

• Main Authors: Dong, Rui, Saheki, Yasunori, Swarup, Sharan, Lucast, Louise, Harper, J. Wade, De Camilli, Pietro
• 其他作者: Lee Kong Chian School of Medicine (LKCMedicine)
• 格式: Article
• 語言: English
• 出版: 2016
• 主題: Endosome-ER contacts; Retromer
• 在線閱讀: https://hdl.handle.net/10356/83386; http://hdl.handle.net/10220/41433
• 機構: Nanyang Technological University

VAP (VAPA and VAPB) is an evolutionarily conserved endoplasmic reticulum (ER)-anchored protein that helps generate tethers between the ER and other membranes through which lipids are exchanged across adjacent bilayers. Here, we report that by regulating PI4P levels on endosomes, VAP affects WASH-dep...