Synthesis and biological evaluation of dihydropyrano-[2,3-c]pyrazoles as a new class of PPARγ partial agonists

• Main Authors: Qvortrup, Katrine, Jensen, Jakob F., Sørensen, Mikael S., Kouskoumvekaki, Irene, Petersen, Rasmus K., Taboureau, Olivier, Kristiansen, Karsten, Nielsen, Thomas Eiland
• Other Authors: Cavalli, Andrea
• Format: Article
• Language: English
• Published: 2017
• Subjects: Partial agonists; Transactivation
• Online Access: https://hdl.handle.net/10356/83481; http://hdl.handle.net/10220/42642
• Institution: Nanyang Technological University

Peroxisome proliferator-activated receptor γ (PPARγ) is a well-known target for thiazolidinedione antidiabetic drugs. In this paper, we present the synthesis and biological evaluation of a series of dihydropyrano[2,3-c]pyrazole derivatives as a novel family of PPARγ partial agonists. Two analogues w...