Transposon insertional mutagenesis in mice identifies human breast cancer susceptibility genes and signatures for stratification

• Main Authors: Chen, Liming, Jenjaroenpun, Piroon, Pillai, Andrea Mun Ching, Ivshina, Anna V., Ow, Ghim Siong, Efthimios, Motakis, Tang, Zhiqun, Tan, Tuan Zea, Lee, Song-Choon, Rogers, Keith, Ward, Jerrold M., Mori, Seiichi, Adams, David J., Jenkins, Nancy A., Copeland, Neal G., Ban, Kenneth Hon-Kim, Kuznetsov, Vladimir Andreevich, Thiery, Jean Paul
• Other Authors: School of Computer Science and Engineering
• Format: Article
• Language: English
• Published: 2017
• Subjects: Breast cancer; Cancer susceptibility
• Online Access: https://hdl.handle.net/10356/83501; http://hdl.handle.net/10220/42595
• Institution: Nanyang Technological University

Robust prognostic gene signatures and therapeutic targets are difficult to derive from expression profiling because of the significant heterogeneity within breast cancer (BC) subtypes. Here, we performed forward genetic screening in mice using Sleeping Beauty transposon mutagenesis to identify candi...