Ultrasensitive Profiling of Metabolites Using Tyramine-Functionalized Graphene Quantum Dots

Ultrasensitive Profiling of Metabolites Using Tyramine-Functionalized Graphene Quantum Dots

Graphene quantum dots (GQDs) are emerging fluorescence reporters attractive for optical sensing, owing to their high photostability, highly tunable photoluminescence, molecular size, atomically thin structure, biocompatibility, and ease of functionalization. Herein, we present a fluorometric sensing...

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Bibliographic Details
Main Authors: Li, Nan, Than, Aung, Wang, Xuewan, Xu, Shaohai, Sun, Lei, Duan, Hongwei, Xu, Chenjie, Chen, Peng
Other Authors: School of Chemical and Biomedical Engineering
Format: Article
Language:English
Published: 2017
Subjects:
Graphene quantum dots
Metabolite detection
Fluorometric biosensing
Online Access:https://hdl.handle.net/10356/83504
http://hdl.handle.net/10220/42637
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Institution: Nanyang Technological University
Language: English
Description
Summary:Graphene quantum dots (GQDs) are emerging fluorescence reporters attractive for optical sensing, owing to their high photostability, highly tunable photoluminescence, molecular size, atomically thin structure, biocompatibility, and ease of functionalization. Herein, we present a fluorometric sensing platform based on tyramine-functionalized GQDs, which is able to detect a spectrum of metabolites with high sensitivity and specificity. Furthermore, multiparametric blood analysis (glucose, cholesterol, l-lactate, and xanthine) is demonstrated. This convenient metabolite profiling technique could be instrumental for diagnosis, study, and management of metabolic disorders and associated diseases, such as diabetes, obesity, lactic acidosis, gout, and hypertension.

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