Hole Transport in A-form DNA/RNA Hybrid Duplexes

DNA/RNA hybrid duplexes are prevalent in many cellular functions and are an attractive target form for electrochemical biosensing and electric nanodevice. However the electronic conductivities of DNA/RNA hybrid duplex remain relatively unexplored and limited further technological applications. Here...

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Main Authors: Wong, Jiun Ru, Shao, Fangwei
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2017
Subjects:
RNA
DNA
Online Access:https://hdl.handle.net/10356/83562
http://hdl.handle.net/10220/42657
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-835622023-02-28T19:22:29Z Hole Transport in A-form DNA/RNA Hybrid Duplexes Wong, Jiun Ru Shao, Fangwei School of Physical and Mathematical Sciences RNA DNA DNA/RNA hybrid duplexes are prevalent in many cellular functions and are an attractive target form for electrochemical biosensing and electric nanodevice. However the electronic conductivities of DNA/RNA hybrid duplex remain relatively unexplored and limited further technological applications. Here cyclopropyl-modified deoxyribose- and ribose-adenosines were developed to explore hole transport (HT) in both DNA duplex and DNA/RNA hybrids by probing the transient hole occupancies on adenine tracts. HT yields through both B-form and A-form double helixes displayed similar shallow distance dependence, although the HT yields of DNA/RNA hybrid duplexes were lower than those of DNA duplexes. The lack of oscillatory periods and direction dependence in HT through both helixes implied efficient hole propagation can be achieved via the hole delocalization and coherent HT over adenine tracts, regardless of the structural variations. MOE (Min. of Education, S’pore) Published version 2017-06-12T08:29:18Z 2019-12-06T15:25:40Z 2017-06-12T08:29:18Z 2019-12-06T15:25:40Z 2017 Journal Article Wong, J. R., & Shao, F. (2017). Hole Transport in A-form DNA/RNA Hybrid Duplexes. Scientific Reports, 7, 40293-. 2045-2322 https://hdl.handle.net/10356/83562 http://hdl.handle.net/10220/42657 10.1038/srep40293 en Scientific Reports © 2017 The Author(s) (Nature Publishing Group). This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ 8 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic RNA
DNA
spellingShingle RNA
DNA
Wong, Jiun Ru
Shao, Fangwei
Hole Transport in A-form DNA/RNA Hybrid Duplexes
description DNA/RNA hybrid duplexes are prevalent in many cellular functions and are an attractive target form for electrochemical biosensing and electric nanodevice. However the electronic conductivities of DNA/RNA hybrid duplex remain relatively unexplored and limited further technological applications. Here cyclopropyl-modified deoxyribose- and ribose-adenosines were developed to explore hole transport (HT) in both DNA duplex and DNA/RNA hybrids by probing the transient hole occupancies on adenine tracts. HT yields through both B-form and A-form double helixes displayed similar shallow distance dependence, although the HT yields of DNA/RNA hybrid duplexes were lower than those of DNA duplexes. The lack of oscillatory periods and direction dependence in HT through both helixes implied efficient hole propagation can be achieved via the hole delocalization and coherent HT over adenine tracts, regardless of the structural variations.
author2 School of Physical and Mathematical Sciences
author_facet School of Physical and Mathematical Sciences
Wong, Jiun Ru
Shao, Fangwei
format Article
author Wong, Jiun Ru
Shao, Fangwei
author_sort Wong, Jiun Ru
title Hole Transport in A-form DNA/RNA Hybrid Duplexes
title_short Hole Transport in A-form DNA/RNA Hybrid Duplexes
title_full Hole Transport in A-form DNA/RNA Hybrid Duplexes
title_fullStr Hole Transport in A-form DNA/RNA Hybrid Duplexes
title_full_unstemmed Hole Transport in A-form DNA/RNA Hybrid Duplexes
title_sort hole transport in a-form dna/rna hybrid duplexes
publishDate 2017
url https://hdl.handle.net/10356/83562
http://hdl.handle.net/10220/42657
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