High Shear Stresses under Exercise Condition Destroy Circulating Tumor Cells in a Microfluidic System

• Main Authors: Regmi, Sagar, Fu, Afu, Luo, Kathy Qian
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2017
• Subjects: Apoptosis; Cancer prevention
• Online Access: https://hdl.handle.net/10356/83565; http://hdl.handle.net/10220/42654
• Institution: Nanyang Technological University

Circulating tumor cells (CTCs) are the primary targets of cancer treatment as they cause distal metastasis. However, how CTCs response to exercise-induced high shear stress is largely unknown. To study the effects of hemodynamic microenvironment on CTCs, we designed a microfluidic circulatory system...