Channel-Inactivating Mutations and Their Revertant Mutants in the Envelope Protein of Infectious Bronchitis Virus

• Main Authors: To, Janet, Surya, Wahyu, Fung, To Sing, Li, Yan, Verdià-Bàguena, Carmina, Queralt-Martin, Maria, Aguilella, Vicente M., Liu, Ding Xiang, Torres, Jaume
• Other Authors: Perlman, Stanley
• Format: Article
• Language: English
• Published: 2017
• Subjects: Coronavirus; Infectious bronchitis virus
• Online Access: https://hdl.handle.net/10356/83630; http://hdl.handle.net/10220/42733
• Institution: Nanyang Technological University

It has been shown previously in the severe acute respiratory syndrome coronavirus (SARS-CoV) that two point mutations, N15A and V25F, in the transmembrane domain (TMD) of the envelope (E) protein abolished channel activity and led to in vivo attenuation. Pathogenicity was recovered in mutants that a...