Early Immune Regulatory Changes in a Primary Controlled Human Plasmodium vivax Infection: CD1c + Myeloid Dendritic Cell Maturation Arrest, Induction of the Kynurenine Pathway, and Regulatory T Cell Activation

• Main Authors: Yeo, Tsin Wen, Woodberry, Tonia, Loughland, Jessica R., Minigo, Gabriela, Burel, Julie G., Amante, Fiona H., Piera, Kim A., McNeil, Yvette, Good, Michael F., Doolan, Denise L., Engwerda, Christian R., McCarthy, James S., Anstey, Nicholas M.
• Other Authors: Adams, John H.
• Format: Article
• Language: English
• Published: 2017
• Subjects: Plasmodium vivax; Treg
• Online Access: https://hdl.handle.net/10356/83710; http://hdl.handle.net/10220/42820
• Institution: Nanyang Technological University

Plasmodium vivax malaria remains a major public health problem. The requirements for acquisition of protective immunity to the species are not clear. Dendritic cells (DC) are essential for immune cell priming but also perform immune regulatory functions, along with regulatory T cells (Treg). An impo...