Lab-on-chip microfluidic impedance measurement for laminar flow ratio sensing and differential conductivity difference detection

We present a microfluidic impedance device for achieving both the flow ratio sensing and the conductivity difference detection between sample stream and reference buffer. By using a flow focusing configuration, with the core flow having a higher conductivity sample than the sheath flow streams, the...

Full description

Saved in:
Bibliographic Details
Main Authors: Kong, Tian Fook, Shen, Xinhui, Marcos, Yang, Chun
Other Authors: School of Mechanical and Aerospace Engineering
Format: Article
Language:English
Published: 2017
Subjects:
Online Access:https://hdl.handle.net/10356/83765
http://hdl.handle.net/10220/42818
https://doi.org/10.21979/N9/3ZE7SK
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Nanyang Technological University
Language: English
id sg-ntu-dr.10356-83765
record_format dspace
spelling sg-ntu-dr.10356-837652023-03-04T17:17:49Z Lab-on-chip microfluidic impedance measurement for laminar flow ratio sensing and differential conductivity difference detection Kong, Tian Fook Shen, Xinhui Marcos Yang, Chun School of Mechanical and Aerospace Engineering Maritime Institute Microscale flows Capacitance We present a microfluidic impedance device for achieving both the flow ratio sensing and the conductivity difference detection between sample stream and reference buffer. By using a flow focusing configuration, with the core flow having a higher conductivity sample than the sheath flow streams, the conductance of the device varies linearly with the flow ratio, with R2 > 0.999. On the other hand, by using deionized (DI)-water sheath flow as a reference, we can detect the difference in conductivity between the buffer of core flow and sheath DI-water with a high detection sensitivity of up to 1 nM of sodium chloride solution. Our study provides a promising approach for on-chip flow mixing characterization and bacteria detection. Published version 2017-07-10T09:25:58Z 2019-12-06T15:31:34Z 2017-07-10T09:25:58Z 2019-12-06T15:31:34Z 2017 Journal Article Kong, T. F., Shen, X., Marcos, & Yang, C. (2017). Lab-on-chip microfluidic impedance measurement for laminar flow ratio sensing and differential conductivity difference detection. Applied Physics Letters, 110(23), 233501-. 0003-6951 https://hdl.handle.net/10356/83765 http://hdl.handle.net/10220/42818 10.1063/1.4984897 en Applied Physics Letters https://doi.org/10.21979/N9/3ZE7SK © 2017 American Institute of Physics (AIP). This paper was published in Applied Physics Letters and is made available as an electronic reprint (preprint) with permission of American Institute of Physics (AIP). The published version is available at: [http://dx.doi.org/10.1063/1.4984897]. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law. 5 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Microscale flows
Capacitance
spellingShingle Microscale flows
Capacitance
Kong, Tian Fook
Shen, Xinhui
Marcos
Yang, Chun
Lab-on-chip microfluidic impedance measurement for laminar flow ratio sensing and differential conductivity difference detection
description We present a microfluidic impedance device for achieving both the flow ratio sensing and the conductivity difference detection between sample stream and reference buffer. By using a flow focusing configuration, with the core flow having a higher conductivity sample than the sheath flow streams, the conductance of the device varies linearly with the flow ratio, with R2 > 0.999. On the other hand, by using deionized (DI)-water sheath flow as a reference, we can detect the difference in conductivity between the buffer of core flow and sheath DI-water with a high detection sensitivity of up to 1 nM of sodium chloride solution. Our study provides a promising approach for on-chip flow mixing characterization and bacteria detection.
author2 School of Mechanical and Aerospace Engineering
author_facet School of Mechanical and Aerospace Engineering
Kong, Tian Fook
Shen, Xinhui
Marcos
Yang, Chun
format Article
author Kong, Tian Fook
Shen, Xinhui
Marcos
Yang, Chun
author_sort Kong, Tian Fook
title Lab-on-chip microfluidic impedance measurement for laminar flow ratio sensing and differential conductivity difference detection
title_short Lab-on-chip microfluidic impedance measurement for laminar flow ratio sensing and differential conductivity difference detection
title_full Lab-on-chip microfluidic impedance measurement for laminar flow ratio sensing and differential conductivity difference detection
title_fullStr Lab-on-chip microfluidic impedance measurement for laminar flow ratio sensing and differential conductivity difference detection
title_full_unstemmed Lab-on-chip microfluidic impedance measurement for laminar flow ratio sensing and differential conductivity difference detection
title_sort lab-on-chip microfluidic impedance measurement for laminar flow ratio sensing and differential conductivity difference detection
publishDate 2017
url https://hdl.handle.net/10356/83765
http://hdl.handle.net/10220/42818
https://doi.org/10.21979/N9/3ZE7SK
_version_ 1759856625547476992