Lab-on-chip microfluidic impedance measurement for laminar flow ratio sensing and differential conductivity difference detection
We present a microfluidic impedance device for achieving both the flow ratio sensing and the conductivity difference detection between sample stream and reference buffer. By using a flow focusing configuration, with the core flow having a higher conductivity sample than the sheath flow streams, the...
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sg-ntu-dr.10356-837652023-03-04T17:17:49Z Lab-on-chip microfluidic impedance measurement for laminar flow ratio sensing and differential conductivity difference detection Kong, Tian Fook Shen, Xinhui Marcos Yang, Chun School of Mechanical and Aerospace Engineering Maritime Institute Microscale flows Capacitance We present a microfluidic impedance device for achieving both the flow ratio sensing and the conductivity difference detection between sample stream and reference buffer. By using a flow focusing configuration, with the core flow having a higher conductivity sample than the sheath flow streams, the conductance of the device varies linearly with the flow ratio, with R2 > 0.999. On the other hand, by using deionized (DI)-water sheath flow as a reference, we can detect the difference in conductivity between the buffer of core flow and sheath DI-water with a high detection sensitivity of up to 1 nM of sodium chloride solution. Our study provides a promising approach for on-chip flow mixing characterization and bacteria detection. Published version 2017-07-10T09:25:58Z 2019-12-06T15:31:34Z 2017-07-10T09:25:58Z 2019-12-06T15:31:34Z 2017 Journal Article Kong, T. F., Shen, X., Marcos, & Yang, C. (2017). Lab-on-chip microfluidic impedance measurement for laminar flow ratio sensing and differential conductivity difference detection. Applied Physics Letters, 110(23), 233501-. 0003-6951 https://hdl.handle.net/10356/83765 http://hdl.handle.net/10220/42818 10.1063/1.4984897 en Applied Physics Letters https://doi.org/10.21979/N9/3ZE7SK © 2017 American Institute of Physics (AIP). This paper was published in Applied Physics Letters and is made available as an electronic reprint (preprint) with permission of American Institute of Physics (AIP). The published version is available at: [http://dx.doi.org/10.1063/1.4984897]. One print or electronic copy may be made for personal use only. Systematic or multiple reproduction, distribution to multiple locations via electronic or other means, duplication of any material in this paper for a fee or for commercial purposes, or modification of the content of the paper is prohibited and is subject to penalties under law. 5 p. application/pdf |
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Microscale flows Capacitance Kong, Tian Fook Shen, Xinhui Marcos Yang, Chun Lab-on-chip microfluidic impedance measurement for laminar flow ratio sensing and differential conductivity difference detection |
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We present a microfluidic impedance device for achieving both the flow ratio sensing and the conductivity difference detection between sample stream and reference buffer. By using a flow focusing configuration, with the core flow having a higher conductivity sample than the sheath flow streams, the conductance of the device varies linearly with the flow ratio, with R2 > 0.999. On the other hand, by using deionized (DI)-water sheath flow as a reference, we can detect the difference in conductivity between the buffer of core flow and sheath DI-water with a high detection sensitivity of up to 1 nM of sodium chloride solution. Our study provides a promising approach for on-chip flow mixing characterization and bacteria detection. |
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School of Mechanical and Aerospace Engineering |
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School of Mechanical and Aerospace Engineering Kong, Tian Fook Shen, Xinhui Marcos Yang, Chun |
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Article |
author |
Kong, Tian Fook Shen, Xinhui Marcos Yang, Chun |
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Kong, Tian Fook |
title |
Lab-on-chip microfluidic impedance measurement for laminar flow ratio sensing and differential conductivity difference detection |
title_short |
Lab-on-chip microfluidic impedance measurement for laminar flow ratio sensing and differential conductivity difference detection |
title_full |
Lab-on-chip microfluidic impedance measurement for laminar flow ratio sensing and differential conductivity difference detection |
title_fullStr |
Lab-on-chip microfluidic impedance measurement for laminar flow ratio sensing and differential conductivity difference detection |
title_full_unstemmed |
Lab-on-chip microfluidic impedance measurement for laminar flow ratio sensing and differential conductivity difference detection |
title_sort |
lab-on-chip microfluidic impedance measurement for laminar flow ratio sensing and differential conductivity difference detection |
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2017 |
url |
https://hdl.handle.net/10356/83765 http://hdl.handle.net/10220/42818 https://doi.org/10.21979/N9/3ZE7SK |
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