Formulating an Ideal Protein Photoresist for Fabricating Dynamic Microstructures with High Aspect Ratios and Uniform Responsiveness
The physical properties of aqueous-based stimuli-responsive photoresists are crucial in fabricating microstructures with high structural integrity and uniform responsiveness during two-photon lithography. Here, we quantitatively investigate how various components within bovine serum albumin (BSA) ph...
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sg-ntu-dr.10356-837782023-02-28T19:37:21Z Formulating an Ideal Protein Photoresist for Fabricating Dynamic Microstructures with High Aspect Ratios and Uniform Responsiveness Lay, Chee Leng Lee, Yih Hong Lee, Mian Rong Phang, In Yee Ling, Xing Yi School of Physical and Mathematical Sciences Bovine Serum Albumin Free-standing Microstructures The physical properties of aqueous-based stimuli-responsive photoresists are crucial in fabricating microstructures with high structural integrity and uniform responsiveness during two-photon lithography. Here, we quantitatively investigate how various components within bovine serum albumin (BSA) photoresists affect our ability to achieve BSA microstructures with consistent stimuli-responsive properties over areas exceeding 104 μm2. We unveil a relationship between BSA concentration and dynamic viscosity, establishing a threshold viscosity to achieve robust BSA microstructures. We also demonstrate the addition of an inert polymer to the photoresist as viscosity enhancer. A set of systematically optimized processing parameters is derived for the construction of dynamic BSA microstructures. The optimized BSA photoresists and processing parameters enable us to extend the two-dimensional (2D) microstructures to three-dimensional (3D) ones, culminating in arrays of micropillars with aspect ratio > 10. Our findings foster the development of liquid stimuli-responsive photoresists to build multifunctional complex 3D geometries for applications such as bioimplantable devices or adaptive photonic systems. NRF (Natl Research Foundation, S’pore) ASTAR (Agency for Sci., Tech. and Research, S’pore) Accepted version 2017-07-04T06:26:35Z 2019-12-06T15:31:52Z 2017-07-04T06:26:35Z 2019-12-06T15:31:52Z 2016 Journal Article Lay, C. L., Lee, Y. H., Lee, M. R., Phang, I. Y., & Ling, X. Y. (2016). Formulating an Ideal Protein Photoresist for Fabricating Dynamic Microstructures with High Aspect Ratios and Uniform Responsiveness. ACS Applied Materials & Interfaces, 8(12), 8145-8153. 1944-8244 https://hdl.handle.net/10356/83778 http://hdl.handle.net/10220/42796 10.1021/acsami.6b02306 en ACS Applied Materials & Interfaces © 2016 American Chemical Society. This is the author created version of a work that has been peer reviewed and accepted for publication by ACS Applied Materials & Interfaces, American Chemical Society. It incorporates referee’s comments but changes resulting from the publishing process, such as copyediting, structural formatting, may not be reflected in this document. The published version is available at: [http://dx.doi.org/10.1021/acsami.6b02306]. 49 p. application/pdf |
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Bovine Serum Albumin Free-standing Microstructures Lay, Chee Leng Lee, Yih Hong Lee, Mian Rong Phang, In Yee Ling, Xing Yi Formulating an Ideal Protein Photoresist for Fabricating Dynamic Microstructures with High Aspect Ratios and Uniform Responsiveness |
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The physical properties of aqueous-based stimuli-responsive photoresists are crucial in fabricating microstructures with high structural integrity and uniform responsiveness during two-photon lithography. Here, we quantitatively investigate how various components within bovine serum albumin (BSA) photoresists affect our ability to achieve BSA microstructures with consistent stimuli-responsive properties over areas exceeding 104 μm2. We unveil a relationship between BSA concentration and dynamic viscosity, establishing a threshold viscosity to achieve robust BSA microstructures. We also demonstrate the addition of an inert polymer to the photoresist as viscosity enhancer. A set of systematically optimized processing parameters is derived for the construction of dynamic BSA microstructures. The optimized BSA photoresists and processing parameters enable us to extend the two-dimensional (2D) microstructures to three-dimensional (3D) ones, culminating in arrays of micropillars with aspect ratio > 10. Our findings foster the development of liquid stimuli-responsive photoresists to build multifunctional complex 3D geometries for applications such as bioimplantable devices or adaptive photonic systems. |
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School of Physical and Mathematical Sciences |
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School of Physical and Mathematical Sciences Lay, Chee Leng Lee, Yih Hong Lee, Mian Rong Phang, In Yee Ling, Xing Yi |
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Article |
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Lay, Chee Leng Lee, Yih Hong Lee, Mian Rong Phang, In Yee Ling, Xing Yi |
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Lay, Chee Leng |
title |
Formulating an Ideal Protein Photoresist for Fabricating Dynamic Microstructures with High Aspect Ratios and Uniform Responsiveness |
title_short |
Formulating an Ideal Protein Photoresist for Fabricating Dynamic Microstructures with High Aspect Ratios and Uniform Responsiveness |
title_full |
Formulating an Ideal Protein Photoresist for Fabricating Dynamic Microstructures with High Aspect Ratios and Uniform Responsiveness |
title_fullStr |
Formulating an Ideal Protein Photoresist for Fabricating Dynamic Microstructures with High Aspect Ratios and Uniform Responsiveness |
title_full_unstemmed |
Formulating an Ideal Protein Photoresist for Fabricating Dynamic Microstructures with High Aspect Ratios and Uniform Responsiveness |
title_sort |
formulating an ideal protein photoresist for fabricating dynamic microstructures with high aspect ratios and uniform responsiveness |
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2017 |
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https://hdl.handle.net/10356/83778 http://hdl.handle.net/10220/42796 |
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1759856837717393408 |