Exploring the induction of preproinsulin-specific Foxp3+ CD4+ Treg cells that inhibit CD8+ T cell-mediated autoimmune diabetes by DNA vaccination

• Main Authors: Stifter, Katja, Schuster, Cornelia, Schlosser, Michael, Boehm, Bernhard Otto, Schirmbeck, Reinhold
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2016
• Subjects: Immunization; Protein design
• Online Access: https://hdl.handle.net/10356/83796; http://hdl.handle.net/10220/41458
• Institution: Nanyang Technological University

DNA vaccination is a promising strategy to induce effector T cells but also regulatory Foxp3(+) CD25(+) CD4(+) Treg cells and inhibit autoimmune disorders such as type 1 diabetes. Little is known about the antigen requirements that facilitate priming of Treg cells but not autoreactive effector CD8(+...