Phosphatidylinositol 4,5-Bisphosphate Is an HCV NS5A Ligand and Mediates Replication of the Viral Genome

Phosphoinositides (PIs) bind and regulate localization of proteins via a variety of structural motifs. PI 4,5-bisphosphate (PI[4,5]P2) interacts with and modulates the function of several proteins involved in intracellular vesicular membrane trafficking. We investigated interactions between PI(4,5)P...

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Main Authors:	Cho, Nam-Joon, Lee, Choongho, Pang, Phillip S., Pham, Edward A., Fram, Benjamin, Nguyen, Khanh, Xiong, Anming, Sklan, Ella H., Elazar, Menashe, Koytak, Elif S., Kersten, Caroline, Kanazawa, Kay K., Frank, Curtis W., Glenn, Jeffrey S.
Other Authors:	School of Materials Science & Engineering
Format:	Article
Language:	English
Published:	2016
Subjects:	Antiviral Strategies Signaling Molecule QCM
Online Access:	https://hdl.handle.net/10356/83833 http://hdl.handle.net/10220/41454
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Institution:	Nanyang Technological University
Language:	English

id	sg-ntu-dr.10356-83833
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spelling	sg-ntu-dr.10356-838332022-02-16T16:30:03Z Phosphatidylinositol 4,5-Bisphosphate Is an HCV NS5A Ligand and Mediates Replication of the Viral Genome Cho, Nam-Joon Lee, Choongho Pang, Phillip S. Pham, Edward A. Fram, Benjamin Nguyen, Khanh Xiong, Anming Sklan, Ella H. Elazar, Menashe Koytak, Elif S. Kersten, Caroline Kanazawa, Kay K. Frank, Curtis W. Glenn, Jeffrey S. School of Materials Science & Engineering Antiviral Strategies Signaling Molecule QCM Phosphoinositides (PIs) bind and regulate localization of proteins via a variety of structural motifs. PI 4,5-bisphosphate (PI[4,5]P2) interacts with and modulates the function of several proteins involved in intracellular vesicular membrane trafficking. We investigated interactions between PI(4,5)P2 and hepatitis C virus (HCV) nonstructural protein 5A (NS5A) and effects on the viral life cycle. NMRC (Natl Medical Research Council, S’pore) 2016-09-19T08:21:14Z 2019-12-06T15:32:56Z 2016-09-19T08:21:14Z 2019-12-06T15:32:56Z 2015 Journal Article Cho, N. J., Lee, C., Pang, P. S., Pham, E. A., Fram, B., Nguyen, K., Xiong, A., Sklan, E. H., Elazar, M., Koytak, E. S., Kersten, C., Kanazawa, K. K., Frank, C. W., & Glenn, J. S. (2015). Phosphatidylinositol 4,5-Bisphosphate Is an HCV NS5A Ligand and Mediates Replication of the Viral Genome. Gastroenterology, 148(3), 616-625. 00165085 https://hdl.handle.net/10356/83833 http://hdl.handle.net/10220/41454 10.1053/j.gastro.2014.11.043 25479136 en Gastroenterology
institution	Nanyang Technological University
building	NTU Library
continent	Asia
country	Singapore Singapore
content_provider	NTU Library
collection	DR-NTU
language	English
topic	Antiviral Strategies Signaling Molecule QCM
spellingShingle	Antiviral Strategies Signaling Molecule QCM Cho, Nam-Joon Lee, Choongho Pang, Phillip S. Pham, Edward A. Fram, Benjamin Nguyen, Khanh Xiong, Anming Sklan, Ella H. Elazar, Menashe Koytak, Elif S. Kersten, Caroline Kanazawa, Kay K. Frank, Curtis W. Glenn, Jeffrey S. Phosphatidylinositol 4,5-Bisphosphate Is an HCV NS5A Ligand and Mediates Replication of the Viral Genome
description	Phosphoinositides (PIs) bind and regulate localization of proteins via a variety of structural motifs. PI 4,5-bisphosphate (PI[4,5]P2) interacts with and modulates the function of several proteins involved in intracellular vesicular membrane trafficking. We investigated interactions between PI(4,5)P2 and hepatitis C virus (HCV) nonstructural protein 5A (NS5A) and effects on the viral life cycle.
author2	School of Materials Science & Engineering
author_facet	School of Materials Science & Engineering Cho, Nam-Joon Lee, Choongho Pang, Phillip S. Pham, Edward A. Fram, Benjamin Nguyen, Khanh Xiong, Anming Sklan, Ella H. Elazar, Menashe Koytak, Elif S. Kersten, Caroline Kanazawa, Kay K. Frank, Curtis W. Glenn, Jeffrey S.
format	Article
author	Cho, Nam-Joon Lee, Choongho Pang, Phillip S. Pham, Edward A. Fram, Benjamin Nguyen, Khanh Xiong, Anming Sklan, Ella H. Elazar, Menashe Koytak, Elif S. Kersten, Caroline Kanazawa, Kay K. Frank, Curtis W. Glenn, Jeffrey S.
author_sort	Cho, Nam-Joon
title	Phosphatidylinositol 4,5-Bisphosphate Is an HCV NS5A Ligand and Mediates Replication of the Viral Genome
title_short	Phosphatidylinositol 4,5-Bisphosphate Is an HCV NS5A Ligand and Mediates Replication of the Viral Genome
title_full	Phosphatidylinositol 4,5-Bisphosphate Is an HCV NS5A Ligand and Mediates Replication of the Viral Genome
title_fullStr	Phosphatidylinositol 4,5-Bisphosphate Is an HCV NS5A Ligand and Mediates Replication of the Viral Genome
title_full_unstemmed	Phosphatidylinositol 4,5-Bisphosphate Is an HCV NS5A Ligand and Mediates Replication of the Viral Genome
title_sort	phosphatidylinositol 4,5-bisphosphate is an hcv ns5a ligand and mediates replication of the viral genome
publishDate	2016
url	https://hdl.handle.net/10356/83833 http://hdl.handle.net/10220/41454
_version_	1725985577480749056

Phosphatidylinositol 4,5-Bisphosphate Is an HCV NS5A Ligand and Mediates Replication of the Viral Genome

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