Manipulating Magnetic 3D Spheroids in Hanging Drops for Applications in Tissue Engineering and Drug Screening

Manipulating Magnetic 3D Spheroids in Hanging Drops for Applications in Tissue Engineering and Drug Screening

Magnetic spheroid manipulation can be carried out in hanging drops to generate distinctly structured heterotypic microtissues through sequential addition of cells or spheroid to homotypic spheroids. These spheroids can also be incorporated in a droplet-based assay to screen for therapeutic efficacy...

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Bibliographic Details
Main Authors: Ho, Vincent H. B., Guo, Wei Mei, Huang, Charlotte L., Ho, Shu Fen, Chaw, Su Yin, Tan, Ern Yu, Ng, Kee Woei, Loo, Joachim Say Chye
Other Authors: School of Materials Science & Engineering
Format: Article
Language:English
Published: 2016
Subjects:
drug screening
magnetic separation
Online Access:https://hdl.handle.net/10356/83848
http://hdl.handle.net/10220/41500
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Institution: Nanyang Technological University
Language: English
Description
Summary:Magnetic spheroid manipulation can be carried out in hanging drops to generate distinctly structured heterotypic microtissues through sequential addition of cells or spheroid to homotypic spheroids. These spheroids can also be incorporated in a droplet-based assay to screen for therapeutic efficacy in prolonged studies. This simple and versatile technique can offer potential benefits in tissue engineering and drug screening applications.

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