Rules of co-occurring mutations characterize the antigenic evolution of human influenza A/H3N2, A/H1N1 and B viruses

• Main Authors: Chen, Haifen, Zhou, Xinrui, Zheng, Jie, Kwoh, Chee-Keong
• Other Authors: School of Computer Science and Engineering
• Format: Article
• Language: English
• Published: 2017
• Subjects: Influenza virus; A/H3N2/H1N1 and B
• Online Access: https://hdl.handle.net/10356/83926; http://hdl.handle.net/10220/42885; https://doi.org/10.21979/N9/H73L8Y
• Institution: Nanyang Technological University

Background: The human influenza viruses undergo rapid evolution (especially in hemagglutinin (HA), a glycoprotein on the surface of the virus), which enables the virus population to constantly evade the human immune system. Therefore, the vaccine has to be updated every year to stay effective. There...