Selective Control of Fear Expression by Optogenetic Manipulation of Infralimbic Cortex after Extinction

• Main Authors: Kim, Hyung-Su, Cho, Hye-Yeon, Augustine, George James, Han, Jin-Hee
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2016
• Subjects: optogenetics; infralimbic cortex
• Online Access: https://hdl.handle.net/10356/83962; http://hdl.handle.net/10220/41595
• Institution: Nanyang Technological University

Evidence from rodent and human studies has identified the ventromedial prefrontal cortex, specifically the infralimbic cortex (IL), as a critical brain structure in the extinction of conditioned fear. However, how IL activity controls fear expression at the time of extinction memory retrieval is unc...