A post-MI power struggle: adaptations in cardiac power occur at the sarcomere level alongside MyBP-C and RLC phosphorylation

• Main Authors: Toepfer, Christopher N., Sikkel, Markus B., Caorsi, Valentina, Vydyanath, Anupama, Torre, Iratxe, Copeland, O'Neal, Lyon, Alexander R., Marston, Steven B., Luther, Pradeep K., Macleod, Kenneth T., West, Timothy G., Ferenczi, Michael Alan
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2016
• Subjects: contractile function; infarction
• Online Access: https://hdl.handle.net/10356/84027; http://hdl.handle.net/10220/41594
• Institution: Nanyang Technological University

Myocardial remodeling in response to chronic myocardial infarction (CMI) progresses through two phases, hypertrophic "compensation" and congestive "decompensation." Nothing is known about the ability of uninfarcted myocardium to produce force, velocity, and power during these cli...