Thiophene-derived polymer dots for imaging endocytic compartments in live cells and broad-spectrum bacterial killing

Thiophene-derived polymer dots for imaging endocytic compartments in live cells and broad-spectrum bacterial killing

In this work, we present a new type of polymer dot synthesized from bithiophene (pTh-Pdot) via a simple and high yield procedure. Owing to their high brightness, excellent photo-stability, good biocompatibility, and molecular size, pTh-Pdots are promising for bioimaging applications. As a proof-of-c...

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Bibliographic Details
Main Authors: Prasad, Kenath Priyanka, Than, Aung, Li, Nan, Alam SK, Mahasin, Duan, Hongwei, Pu, Kanyi, Zheng, Xinting, Chen, Peng
Other Authors: School of Chemical and Biomedical Engineering
Format: Article
Language:English
Published: 2017
Subjects:
Polymer dots
Bioimaging
Online Access:https://hdl.handle.net/10356/84083
http://hdl.handle.net/10220/42917
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Institution: Nanyang Technological University
Language: English
Description
Summary:In this work, we present a new type of polymer dot synthesized from bithiophene (pTh-Pdot) via a simple and high yield procedure. Owing to their high brightness, excellent photo-stability, good biocompatibility, and molecular size, pTh-Pdots are promising for bioimaging applications. As a proof-of-concept demonstration, pTh-Pdots are herein employed to track the endocytic pathway in live cells. Furthermore, we show that these polymeric nanoparticles can serve as potent antibacterial agents by making use of their ability to disrupt bacterial membranes and high peroxidase mimicking activity.

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