Preclinical safety and immunogenicity evaluation of bioactive antimicrobial peptides

• Main Author: Koh, Phay Chung
• Other Authors: Navin Kumar Verma
• Format: Student Research Poster
• Language: English
• Published: 2016
• Subjects: Antimicrobial peptide; Immunogenicity
• Online Access: https://hdl.handle.net/10356/84143; http://hdl.handle.net/10220/41624
• Institution: Nanyang Technological University

Background: Bioactive peptides with antimicrobial properties have many potential applications, ranging from food preservation to the treatment of drug-resistant infections. However, some of these peptides may induce unwanted toxicity or immunogenicity. Regulatory agencies, therefore, require rigours safety assessments of all the therapeutic peptides using appropriate biological model systems. Our collaborating group has developed a novel series of AMPs with broad spectrum antimicrobial activities. Aim: To examine possible cytotoxicity and immunogenicity (if any) of the four AMPs (Pep 1, Pep 2, Pep 3, & Pep 4) using cell culture model systems. [2nd Award]