Progress in Understanding the Molecular Basis Underlying Functional Diversification of Cyclic Dinucleotide Turnover Proteins

• Main Authors: Römling, Ute, Liang, Zhao-Xun, Dow, J. Maxwell
• Other Authors: Margolin, William
• Format: Article
• Language: English
• Published: 2017
• Subjects: GGDEF domain; Cyclic dinucleotide second messenger
• Online Access: https://hdl.handle.net/10356/84161; http://hdl.handle.net/10220/43568
• Institution: Nanyang Technological University

Cyclic di-GMP was the first cyclic dinucleotide second messenger described, presaging the discovery of additional cyclic dinucleotide messengers in bacteria and eukaryotes. The GGDEF diguanylate cyclase (DGC) and EAL and HD-GYP phosphodiesterase (PDE) domains conduct the turnover of cyclic di-GMP. T...