Array-based sequencing of filaggrin gene for comprehensive detection of disease-associated variants

Array-based sequencing of filaggrin gene for comprehensive detection of disease-associated variants

The filaggrin gene (FLG) is essential for skin differentiation and epidermal barrier formation. FLG loss-of-function (LoF) variants are associated with ichthyosis vulgaris and the major genetic risk factor for developing atopic dermatitis (AD).1, 2, 3 Genetic stratification of patients with AD accor...

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Bibliographic Details
Main Authors: Wong, Colin C. X. F., Denil, Simon L. I. J., McLean, W. H. Irwin, Smith, Frances J. D., Common, John E. A., Tang, Mark B. Y., Foo, Jia Nee, Chen, Huijia, Tay, Angeline Su Ling, Haines, Rebecca L., Sandilands, Aileen, Lane, E. Birgitte, Liu, Jianjun
Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
Format: Article
Language:English
Published: 2019
Subjects:
Filaggrin Gene
Disease-associated Variants
Science::Medicine
Online Access:https://hdl.handle.net/10356/84165
http://hdl.handle.net/10220/49132
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/84165
http://hdl.handle.net/10220/49132

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