The effect of linker DNA on the structure and interaction of nucleosome core particles

• Main Authors: Huang, Yen-Chih, Su, Chun-Jen, Korolev, Nikolay, Berezhnoy, Nikolay V., Wang, Sai, Soman, Aghil, Chen, Chun-Yu, Chen, Hsin-Lung, Jeng, U-Ser, Nordenskiöld, Lars
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2019
• Subjects: Nucleosome; Science::Biological sciences; DNA
• Online Access: https://hdl.handle.net/10356/84169; http://hdl.handle.net/10220/50103
• Institution: Nanyang Technological University

In eukaryotes, the compaction of chromatin fibers composed of nucleosome core particles (NCPs) connected by a linker DNA into chromosomes is highly efficient; however, the underlying folding mechanisms remain elusive. We used small angle X-ray scattering (SAXS) to investigate the influence of linker...