Cyclin-Dependent Kinase-Dependent Phosphorylation of Sox2 at Serine 39 Regulates Neurogenesis

• Main Authors: Lim, Shuhui, Bhinge, Akshay, Bragado Alonso, Sara, Aksoy, Irene, Aprea, Julieta, Cheok, Chit Fang, Calegari, Federico, Stanton, Lawrence W., Kaldis, Philipp
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2017
• Subjects: Neural stem cells; Cell cycle regulation
• Online Access: https://hdl.handle.net/10356/84199; http://hdl.handle.net/10220/43570
• Institution: Nanyang Technological University

Sox2 is known to be important for neuron formation, but the precise mechanism through which it activates a neurogenic program and how this differs from its well-established function in self-renewal of stem cells remain elusive. In this study, we identified a highly conserved cyclin-dependent kinase...