Structural investigation of the ubiquitylation of nucleosome core particles by the E3 ligase BRCA1/BARD1

• Main Author: Sivaraman, Hariharan
• Other Authors: Daniela Rhodes
• Format: Theses and Dissertations
• Language: English
• Published: 2019
• Subjects: Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/84338; http://hdl.handle.net/10220/49322
• Institution: Nanyang Technological University

Based on the reports from the American Cancer Society, cancer is the leading cause of death in the world, followed by heart diseases. Scientific methods and technology for early detection and intervention would save not only millions of lives but also billions of dollars. Among the types of cancers,...